❖ Doctors have started the trials on hundreds of patients for the world's first personalised mRNA cancer vaccine for melanoma. 

❖ Melanoma, the leading cause of skin cancer deaths globally, affects approximately 132,000 people annually.

❖ The vaccine, called mRNA-4157 (V940), is a personalised treatment that activates the immune system to fight a patient's specific cancer.

❖ It targets tumour neoantigens, which are unique markers found on tumours and can be recognised by the immune system